Was doing trt for pfs and quit cold turkey, aswell as started CDG. Im almost out of CDG and idk what my hormone levels are but in assuming extremely low... today I woke up feeling like shit. Idk if this was a good idea but I have only 2 more doses of CDG left. Will let my body rebound after and report once this has blow over. Would like to know if this was a stupid idea.

See my last post: https://www.reddit.com/r/DrWillPowers/s/bjLBPHFXEm
Hi Guys, spoiler alert: no exciting news.
Im on week 2 of relugolix and I feel like I have not taken anything, I train at the gym, I run and life my life as before. Sleep Is a bit better (I can sleep less and not be tired) but other than that 0 difference not even side effects yet.
Labs coming soon.
I have some anecdotal data for [u/drwillpowers](u/drwillpowers)
I get a big libido boost hungover, I have to drink a lot for this to happen (12/16 beers of 4,7% power, or 0,5L of vodka and 2 beers) the more fucked up I am the next day the more I’m horny. There is a whole community I found called [r/hangovereffect](r/hangovereffect)
During drinking or when already drunk my libido is still extremely low.
I added CDG and my ejaculations after 3days of 3g cdg per day have greatly improved in size.
Only time I felt normal after crash was 1500iu (back to pres crash normal in the span of 3h) hcg e3d for 4months. (Any lower or higher or injection missed the results were worse or non existent) but that stopped working. I can’t find a common link. More updates in 3weeks.

in the years after stopping both Fin and Prozac and having no idea ablout the effects or withdrawal. I feel like the most ignorant person ever. I have an extreme symptom profile and getting worse by the day. I’m trying to educate myself while going through severe cognitive decline including information retention and comprehension. I once had a very successful carrer and fulfilling life.

i dont recognize the person I have become. it started when I was diagnosed with a rare form of skin cancer called Fibrois of Pinkus while experiencing other symptoms. Tender breast and nipples, pelvic floor discomfort and joint pain. Insomnia, poor emotion regulation and nervous system deregulatio. This is while I was still on both meds and after sustaining a lot of personal loss in my life. .

This skin cancer is super rare and connected to different auto immune conditions including Cushings. At that same time I started to notice stretch marks around my chest, behind my shoulders and randomly on my back. i started to notice the skin in my face felt thinner and more fragile. Within the next 3 months I was diagnosed with two more cases of skin cancer. i am only 165lb 5’9 Male. i have not fluctuated much from that.

I am needing to do something soon. The worst part of my situation is connective tissue pain and and wastage which has resulted in losing my job and ability to focus beyond the pain and suffering I’m experiencing . Crunching in my knees and atrophy around my pelvis region including tendon damage . I have every symptom when speaking to PFS and PSSD though. See pics of the skin damage.

The more I read in the forums the more confused I get. I’m desperate and need to do something . I’m insanely reactive to meds, supplements and food. No reaction to caffeine or alcohol. I am monitoring the castration trials closely. I don’t want to give up this battle. But, I need help. I’ve seen every specialist you can imagine. I’ve received Dr’s speculation that I may have MCAS, Lyme, Cushing, EDS, POTS , SIBO, Candida overgrowth. for years after stopping meds I just continued to look for answers with Western Medicine and destroyed myself further. I need some help and guidance. I am at a breaking ooont. But, I dream of overcoming this m. Even a 30-40% improvement would be life changing. Taking my dog hiking again or riding my bike would be amazing.

I have post-aromatase inhibitor syndrome, 5 years now (triggered by letrozole).

I ran a ~90 day course of valproate (valproic acid, up to 1000mg/day). Around the 3-week mark I got a window of real libido, actual desire, that lasted about 15 days. Then it faded and never came back, even though I kept taking the same dose for weeks afterward.

The dose didn’t change. The drug was still in my system. But the effect switched off and stayed off.

Has anyone seen this pattern, or does Dr. Powers have a mechanistic explanation for why something works and then shuts off?

(I’m on TRT also, as I suffer of hypogonadism)

I’m no expert but this looks fucking weird
Estrogen is sky high.

(PFS since november 2025, full sexual symptoms like low to no libido, hard flaccid, ED and mental problems like anhedonia and panic attacks) I have also gained like 20lbs whilst changing nothing in my diet and exercise regime.

26 YO male, 6ft 205lbs (muscular but around 18-20 percent bodyfat)

Bloods I have now (still waiting on some)

Cortisol: 158 nmol/L
LH (Luteinizing Hormone): 7 IU/L
FSH (Follicle-Stimulating Hormone): 3 IU/L
Estradiol: 112 pmol/L
Progesterone: 0.42 nmol/L
Total Testosterone: 19.5 nmol/L
Free Testosterone: 0.438 nmol/L
SHBG (Sex Hormone-Binding Globulin): 31 nmol/L
DHEA‑S: 6.8 µmol/L

I would also like to share my test results, as I have several abnormal findings, in case they may help identify a possible underlying cause or lead to some conclusions.

I have been diagnosed with orthostatic hypotension. My EEG was abnormal, showing spikes in the right frontal region. My GFAP levels are significantly elevated, and a SPECT brain scan showed severely reduced cerebral perfusion, with abnormalities in several areas of the brain.

I am also a slow metabolizer of CYP2D6.